Chromosomal alterations of Candida albicans are associated with the gain and loss of assimilating functions
نویسندگان
چکیده
منابع مشابه
Variation in assimilating functions occurs in spontaneous Candida albicans mutants having chromosomal alterations.
In this study, four clinical isolates and over 100 colony morphology mutants, previously derived spontaneously from strain 3153A during growth on glucose medium, were examined for their utilization of 21 carbon and 3 nitrogen sources at various growth temperatures. The results demonstrated extensive variability in the pattern of assimilation among the mutants and strains, including both the gai...
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15 صفحه اولChromosomal variations in Candida albicans.
We report here the separation of chromosomal DNA molecules from the diplokl pathogenic yeast C. albicans by field inversion gel electrophoresls (FIOEK1). Our earlier work on C. albicans ATCC strain 10261 revealed a pulsed field gel electrophoretic pattern of six bands, two of which were possibly doublets (2). In the present study we found that FIGE gave superior resolution with uniform DNA mobi...
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UV and X-ray sensitivity of Candida albicans laboratory strains and mutants having chromosomal alterations.
Utilization of L-sorbose, D-arabinose or primary fluconazole resistance in Candida albicans are controlled by copy number of specific chromosomes. On the other hand, spontaneous morphological mutants have a wide range of chromosomal alterations. We have investigated the UV and X-ray sensitivity of these mutants, as well as C. albicans laboratory strains. While L-sorbose utilizing mutants had no...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1994
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.176.11.3231-3241.1994